陳怜均

系所資訊

重要訊息

個人資訊 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴

	姓名	陳怜均
	職稱	副教授
	電話	03-5381183-8151
	辦公室位置	H505-2
	信箱	d8801004@mail.ypu.edu.tw

學歷 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴

臺北醫學大學藥學系博士

國立中興大學食品暨應用生物科技學系研究所碩士

國立中興大學食品暨應用生物科技學系學士

經歷 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴

光宇學校財團法人元培醫事科技大學講師專任

光宇學校財團法人元培醫事科技大學教師兼任

台昇生物科技顧問股份有限公司臨床部專案研究員專任

台昇生物科技顧問股份有限公司藥品非臨床試驗分析實驗室分析研究員專任

臺北醫學大學藥學系(藥劑組) 研究助理專任

研究領域 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴

Ø 學名藥劑型處方開發

- 口服吸收劑型

- 經皮吸收劑型

- 口腔黏膜吸收劑型

Ø 藥物分析

Ø 藥物動力學研究

Ø 臨床試驗設計規劃及執行

研究計畫 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴

1.	由熔噴不織布與可見光交聯水膠組合之生物黏著性互穿聚合物網络水膠於經皮藥物輸送之新穎應用(MOST 107- 2314 -B - 264- 002)，國科會 (107/08/01 ~ 108/07/31；主持人)
2.	新型製備 Carfilzomib 血清白蛋白奈米粒子以提升藥物動力學特性及其單獨或併用Paclitaxel 血清白蛋白奈米粒子之抗腫瘤效果(MOST 108- 2314 -B - 264 – 001)，國科會 (108/08/01 ~ 109/07/31；主持人)
3.	開發可注射原位交聯型玻尿酸水膠載體應用於皮下遞送雙特異性T細胞接合抗體以提高癌症治療效果及降低細胞因子釋放綜合徵之風險 (MOST 109- 2314 -B - 264- 001)，國科會 (109/08/01 ~ 110/07/31；主持人)
4.	新型製備 Carfilzomib 血清白蛋白奈米粒子以提升藥物動力學特性及其單獨或併用Paclitaxel 血清白蛋白奈米粒子之抗腫瘤效果-2 (MOST 110-2221-E-264-002)，國科會 (110/08/01 ~ 111/07/31；主持人)
5.	以SiliaCat-TEMPO 氧化靈芝渣的綠色製備法製備新型基質支架作為骨組織工程和再生之研究 (MOST 111-2221-E-264 -002 -MY2)，國科會 (111/08/01 ~ 113/07/31；主持人)
6.	靈芝渣以凍融循環生成之Sacchachitin奈米纖維作為新型基質支架用於促進骨再生和改善糖尿病傷口癒合之研究 (NSTC 113-2221-E-264 -001 -MY2)，國科會 (113/08/01 ~ 115/07/31；主持人)

企業委託產學合作計畫 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴

1.	新型傷口敷料之研發與其物性評估，睿昶興業有限公司(107/06/01 ~ 108/03/31；主持人)
2.	Vitamin D3 微膠體口服液改善諮詢研究計畫，寶齡富錦生技股份有限公司(107/06/01 ~ 108/05/31；主持人)
3.	Vitamin C & Maca圓粒劑型產品開發研究計畫，寶齡富錦生技股份有限公司(107/09/01 ~ 108/08/31；主持人)
4.	Hybrid Dermal Filler (PLLA 微球/玻尿酸) 改善諮詢研究計畫，寶齡富錦生技股份有限公司(109/01/01 ~ 109/12/31；主持人)
5	經皮貼片劑型改善諮詢研究計畫，得生製藥股份有限公司 (110/01/01 ~ 110/12/31；主持人)
6.	玻尿酸微針產品改善諮詢研究計畫，寶齡富錦生技股份有限公司 (110/02/01 ~ 111/01/31；主持人)
7.	Sacchachitin 水溶性改善諮詢研究計畫，寶齡富錦生技股份有限公司 (111/08/01 ~ 112/07/31；主持人)
8.	靈芝玻尿酸之製備及其在生醫臨床應用諮詢研究計畫，寶齡富錦生技股份有限公司 (112/11/01 ~ 114/10/31；主持人)

期刊論文 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴

1.	Sheu, M. T., Lin, S. Y., Cheng, W. J., Lin, H. L., Hsieh, C. M., Ho, H. O., Chen, L. C., & Wu, M. H. (2024) Bioactive matrix scaffold of oxidized sacchachitin via green catalyst of siliacat tempo for enhancing bone regeneration. Carbohydrate Polymer Technologies and Applications, 8: 100576.
2.	Lin, C. J., Lin, H. L., You, W. C., Ho, H. O., Sheu, M. T., Chen, L. C., & Cheng, W. J. (2023) Composite Hydrogels of Ultrasound-Assisted-Digested Formic Acid-Decellularized Extracellular Matrix and Sacchachitin Nanofibers Incorporated with Platelet-Rich Plasma for Diabetic Wound Treatment. Journal of Functional Biomaterials, 14 (8): 423.
3.	Liang, Y. K., Cheng, W. T., Chen, L. C., Sheu, M. T., & Lin, H. L. (2023) Development of a Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) of Ciprofloxacin Hydrochloride. Pharmaceutics, 15(5): 1428.
4.	Chen, L. C.^#, Lin, S. Y.^#, Cheng, W. J., Sheu, M. T., Chung, C. Y., Hsu, C. H., & Lin, H. L. (2023) Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery. Drug Delivery, 30(1): 2158964.
5.	Liu, Y. H.^#, Chen, L. C.^#, Cheng, W. T.^#, Wei, P. S., Hsieh, C. M., Sheu, M. T., Lin, S. Y., Ho, H. O., & Lin, H. L. (2023) Synergistic Combination of Irinotecan and Rapamycin Orally Delivered by Nanoemulsion for Enhancing Therapeutic Efficacy of Pancreatic Cancer. Pharmaceutics, 15(2): 473.
6.	Cheng, W. J., Lin, S. Y., Chuang, K. H., Chen, M., Ho, H. O., Chen, L. C., Hsieh, C. M., & Sheu, M. T. (2022) Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer. International Journal of Nanomedicine, 17: 5353-5374.
7.	Chen L.-C.^#, Lin S.-Y.^#, Sheu M.-T., Su C.-H., Lin H.-L., Hsieh C.-M. (2021) Fabrication and characterization of Rhizochitosan and its incorporation with platelet concentrates to promote wound healing. Carbohydrate Polymers, 268: 118239.
8.	Lin H.-L., Cheng W.-T., Chen L.-C., Ho H.-O., Lin S.-Y., Hsieh C.-M. (2021) Honokiol/magnolol-loaded self-assembling lecithin-based mixed polymeric micelles (lbMPMs) for improving solubility to enhance oral bioavailability. International Journal of Nanomedicine, 16: 651-665.
9.	Cheng W.-T., Ho H.-O., Lin S.-Y., Liu D.-Z., Chen L.-C.^, Sheu M.-T.^ (2021) Carfilzomib and Paclitaxel Co-Loaded Protein Nanoparticles an Effective Therapy Against Pancreatic Adenocarcinomas. Int J Nanomedicine. 16: 6825-6841.
10.	Cheng W.-J., Lin S.-Y., Chen M., Chen L.-C., Ho H.-O., Chuang K.-H., Sheu M.-T. (2021) Active Tumoral/Tumor Environmental Dual-Targeting by Non-Covalently Arming with Trispecific Antibodies or Dual-Bispecific Antibodies on Docetaxel-Loaded mPEGylated Nanocarriers to Enhance Chemotherapeutic Efficacy and Minimize Systemic Toxicity. International Journal of Nanomedicine, 16: 4017-4030.
11.	Wu M.-H., Wang W., Chao F.-C., Hsieh C.-M., Chen L.-C., Lin H.-L., Ho H.-O., Huang T.-J., Sheu M.-T. (2021) One-pot fabrication of sacchachitin for production of TEMPO- oxidized sacchachitin nanofibers (TOSCNFs) utilized as scaffolds to enhance bone regeneration. Carbohydrate Polymers, 254: 117270.
12.	Lin H.-L.^#, Chen L.-C.^#, Cheng W.-T., Cheng W.-J., Ho H.-O., Sheu M.-T. (2020) Preparation and characterization of a novel swellable and floating gastroretentive drug delivery system (sfGRDDS) for enhanced oral bioavailability of nilotinib. Pharmaceutics, 12 (2): 137.
13.	Chao F.-C., Wu M.-H., Chen L.-C., Lin H.-L., Liu D.-Z., Ho H.-O., Sheu M.-T. (2020) Preparation and characterization of chemically TEMPO-oxidized and mechanically disintegrated sacchachitin nanofibers (SCNF) for enhanced diabetic wound healing. Carbohydrate Polymers, 229: 115507.
14.	Lin H.-L., Wu T.-H., Ho H.-O., Chao F.-C., Wu M.-H., Liu D.-Z., Chen L.-C.^, Sheu M.-T.^, (2020) TEMPO-oxidized sacchachitin nanofibers (TOSCNFs) combined with platelet-rich plasma (PRP) for management of dry eye syndrome. International Journal of Nanomedicine, 15: 1721- 1730.

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